For several centuries, far-field optical microscopy remains a key instrument in many scientific disciplines including physical, chemical and biomedical research. Unfortunately, biological tissues strongly scatter light, making high-resolution deep-tissue imaging impossible for traditional light field microscopy. We are creating a breakthrough method for in vivo bioimaging. In this project we will develop new endo-microscopy approaches for deep-tissue ultra-fast neuroimaging with the spatial resolution beyond the diffraction limit.
In collaboration with the LaserLaB Amsterdam and Center for Neurogenomics and Cognitive Research, VU, Amsterdam, super-resolution endomicroscopy will be applied to imaging the functional distribution of biomarkers in brain tissue. The new endoscopic method will allow to visualize subcellular structures, such as dendritic spines, and study neuropeptide transmission deep inside the intact brain. It will provide a new tool to investigate the role of neuropeptides at a functional level and their implication in neurodegenerative diseases.
Has your interest been piqued? You can join the team and help to work on this breakthrough method! There is an opening for a master’s student, preferably doing their thesis, to perform measurements with the current set-up and possibly to rebuild it further in the future. Please contact Max Verweg (firstname.lastname@example.org) or dr. Lyuba Amitonova (email@example.com) for further information and to apply for the position.